Oral dantrolene
نویسندگان
چکیده
منابع مشابه
Dantrolene and lymphocytic lymphoma.
A patient is reported who was on prolonged treatment with dantrolene for spastic paraplegia; he developed a malignant lymphoma which led to his death.
متن کاملHepatitis from dantrolene sodium.
The clinical course and histological changes in the liver during a presumed adverse reaction to the drug dantrolene sodium are described in four patients. After a typical prodrome one developed a moderately severe hepatitis-like illness. Another also had a prodrome but never became jaundiced. In the other two, abnormal liver function tests were detected on routine screening. In each case liver ...
متن کاملThe effect of long-term oral dantrolene on the neuromuscular action of rocuronium: a case report
Oral dantrolene causes a dose-dependent depression of skeletal muscle contractility. A 52-year-old man treated with oral dantrolene for spasticity after spinal cord injury was scheduled to undergo irrigation and drainage of a thigh abscess under general anesthesia. He had taken 50 mg oral dantrolene per day for 3 years. Under standard neuromuscular monitoring, anesthesia was performed with prop...
متن کاملDantrolene sodium and management of malignant hyperthermia.
Malignant hyperthermia (MH) is an inherited muscle disorder suffered by patients who undergo a stressful situation or acute trauma or who have been given certain anesthetic agents. 1,2 MH has been called the most common cause of anesthesiarelated death in North America, contributing a large percentage of the 15,000 to 20,000 of such deaths recorded annually.3 The 53% mortality rate of today com...
متن کاملDantrolene requires Mg2+ to arrest malignant hyperthermia.
Malignant hyperthermia (MH) is a clinical syndrome of skeletal muscle that presents as a hypermetabolic response to volatile anesthetic gases, where susceptible persons may develop lethally high body temperatures. Genetic predisposition mainly arises from mutations on the skeletal muscle ryanodine receptor (RyR). Dantrolene is administered to alleviate MH symptoms, but its mechanism of action a...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 2004
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.2004.03979.x